Designing polysaccharide-based antibacterial biomaterials for wound healing applications
نویسندگان
چکیده
In this study, the development and characterization of novel polymer blends based on chitosan-poly (vinyl alcohol) and physically cross-linked by freeze-thaw method for possible use in a variety of biomedical application is reported. The present investigation deals with designing savlon-loaded blend hydrogels (coined as cryogels) of poly (vinyl alcohol) (PVA) and chitosan by repeated freeze-thaw method and their characterization by SEM and FTIR techniques. The FTIR spectra clearly reveal that savlon-loaded chitosan and PVA blends are bonded together through hydrogen bonding. The SEM analysis suggests that cryogels show a well-defined porous morphology. The prepared cryogels were also investigated for swelling and deswelling behaviors. The results reveal that both the swelling and deswelling behaviors greatly depend on factors like chemical composition of the cryogels, number of freeze-thaw cycles, pH and temperature of the swelling bath. The savlon-loaded blends were also investigated for their in vitro blood compatibility and antibacterial activity.
منابع مشابه
Chitin and Chitosan: Structure, Properties and Applications
Chitin and chitosan are the most abundant natural amino polysaccharide that are non-toxic, biodegradable and biocompatible. They have become of great interest not only as an underutilized resource, but also as a new functional material of high potential in various fields. They are biopolymers having immense structural possibilities for chemical and mechanical modifications to generate novel pro...
متن کاملHemocompatibility assessment and drug release kinetics investigation from materials based on electrospun nanofibers
Objective(s): Polymeric nanofiber has a huge potential for a various biomedical applications such as wound healing and orthopedic implant. Since most of the future applications of therapeutic nanofiber are interacting with human blood components, it is important to investigate hemocompatibility. Methods: In this study, nanofibers with antibacterial properties were synthesizedby elec...
متن کاملFacile preparation of antibacterial, highly elastic silvered polyurethane nanofiber fabrics using silver carbamate and their dermal wound healing properties.
In this study, polycarbonate diol/isosorbide-based antibacterial polyurethane nanofiber fabrics containing Ag nanoparticles were prepared by electrospinning process. Bio-based highly elastic polyurethane was prepared from hexamethylene diisocyanate and isosorbide/polycarbonate diol (8/2) by a simple one-shot bulk polymerization. Ag nanoparticles were formed using simple thermal reduction of sil...
متن کاملChitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials
Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and c...
متن کاملDevelopment of antimicrobial chitosan based nanofiber dressings for wound healing applications
Objective(s): Chitosan based composite fine fibers were successfully produced via a centrifugal spinning technology. This study evaluates the ability of the composites to function as scaffolds for cell growth while maintaining an antibacterial activity. Materials and methods: Two sets of chitosan fiber composites were prepared, one filled with anti-microbial silver nanoparticles and another on...
متن کامل